Sioe Lie joined CCM as missionary in 1989. She worked with the Peace Evangelical Centre of Hong Kong in their Macau church-planting ministry. From 1993 to 1995 Sioe Lie worked with a local church in Macau to evangelize and to provide training and counseling to the new immigrants and contract laborers from China. Since 1995 Sioe Lie has been working with the Industrial Evangelistic Fellowship Macau Centre. She makes friend with the contract laborers to lead them to Christ, and she helps them to experience God's love in their daily lives through various activities, services, and visitation.